|
Adenoma
|
0.400 |
Biomarker
|
group |
LHGDN |
[Expressions of beta-catenin, p53 and proliferating cell nuclear antigen in the carcinogenesis of colorectal adenoma].
|
12515622 |
2002 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
With the combination of stabilized β-catenin and elevated Igf2 expression, adrenal glands were larger, displayed earlier onset of hyperplasia, and developed more frequent macroscopic adenomas (as well as one carcinoma).
|
22800756 |
2012 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
With beta-catenin as a molecular marker, the adenoma-carcinoma sequence can be considered to be a minor pathway in gallbladder carcinogenesis.
|
11196159 |
2001 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We show that D3 is a direct transcriptional target of the β-catenin/TCF complex; its expression was higher in human intestinal adenomas and carcinomas than in healthy intestinal tissue.
|
22771508 |
2012 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We show here that in this patient with mild GSDIa without recurrent hypoglycaemic episodes, adenoma and carcinoma formation still occurred and that malignant transformation of adenoma here is associated with CTNNB1 mutations and a typical mRNA profile of a beta-catenin activated lesion.
|
20447711 |
2010 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We sequenced PRKACA, GNAS and CTNNB1 genes in 108 patients, including 60 patients with CPAs (57 with unilateral and three with bilateral adenomas), 13 with nonfunctional adenomas, 12 with adrenocortical carcinomas (ACCs), 15 with primary bilateral macronodular hyperplasia (PBMAH) and eight with aldosterone and cortisol cosecreting adenomas.
|
27296931 |
2016 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We searched for alterations in the APC mutation cluster region, the whole coding regions of TGF-beta type II receptor (RII) and beta-catenin exon 3 in 16 cases of cancer in adenomas of the colon.
|
9566701 |
1998 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We report, for the first time, beta-catenin mutations in adenomas associated with PPNAD, further implicating Wnt-beta-catenin signalling in tumorigenesis linked to bilateral adrenal hyperplasias.
|
18419788 |
2008 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We report a case of a well-differentiated hepatocellular neoplasm with Dubin-Johnson-like pigment displaying histological features overlapping with a beta-catenin mutated inflammatory adenoma and a well-differentiated hepatocellular carcinoma in a non-cirrhotic liver.
|
26663015 |
2015 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
We report a case of a peliotic adenoma that was morphologically consistent with a β-catenin wild-type hepatocellular adenoma but harbored a β-catenin mutation by molecular analysis.
|
24997695 |
2014 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We found that SHARP gene and protein expression is elevated in human colon and ovarian endometrioid adenocarcinomas and mouse colon adenomas and carcinomas carrying gene defects leading to beta-catenin dysregulation.
|
17234755 |
2007 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
We evaluated the cellular localization of beta-catenin in thyroid carcinomas associated (n = 4) or not associated (n = 173) with FAP, since loss of functional protein of the adenomatous polyposis coli (APC) gene leads to nuclear accumulation of beta-catenin in adenomas and carcinomas of the FAP colon.
|
11092973 |
2000 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
We corroborated the Wnt/APC signalling pathway on the NT1 receptor promoter activation with human colon carcinogenesis, and showed that NT1 receptor gene activation was perfectly correlated with nuclear or cytoplasmic beta-catenin localization while NT1 receptor was absent when beta-catenin was localized at the cell-cell junction in early adenomas of patients with familial adenomatous polyposis, hereditary non-polyposis colorectal cancer and loss of heterozygosity tumours.
|
16299383 |
2006 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Using human CRC cells harboring different Wnt/β-catenin pathway mutations in APC/KRAS or β-catenin/KRAS genes, and both genetic and pharmacological knockdown approaches, we show that oncogenic β-catenin signaling negatively regulates the expression of NHERF1 (Na<sup>+</sup>/H<sup>+</sup> exchanger 3 regulating factor 1), a PDZ-adaptor protein that is usually lost or downregulated in early dysplastic adenomas to exacerbate nuclear β-catenin activity.
|
29551770 |
2018 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Tumors represented adenoma stages along with the nuclear accumulation of β-catenin.
|
27037682 |
2016 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Together, this may suggest that two molecular pathways, intermediate methylation associated with KRAS mutations and LST-G morphology, and low methylation associated with CTNNB1 activation and LST-NG morphology, might be involved in LST development, and that involvement of TP53 mutations could be important in both subtypes in the development from adenoma to cancer.
|
24590867 |
2014 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
CTD_human |
Thus, beta-catenin mutations may have more importance in the genesis of adenomas than ACF or adenocarcinomas in rat colon carcinogens by PhIP.
|
10965019 |
2000 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
These suggest that alteration of other genes is primarily responsible for the nuclear translocation of beta-catenin in gastric adenomas.
|
12926124 |
2003 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
These findings suggest that, following APC loss, CtBP1 contributes to adenoma initiation as a first step, whereas KRAS activation and beta-catenin nuclear localization promote adenoma progression to carcinomas as a second step.
|
19450512 |
2009 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
These data support the following hypotheses derived from sporadic colorectal tumors: beta-catenin mutations are generally an alternative to mutations at APC, MSI is not usually an early phenomenon in colorectal tumorigenesis, and K-ras mutations are more typical of large- and moderate-sized adenomas.
|
10681434 |
2000 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
There was less loss of membranous beta-catenin staining and less nuclear beta-catenin accumulation in resistant adenomas compared with baseline adenomas from the same (sulindac-resistant) patients (P < 0.01) or baseline adenomas from responsive patients (P < 0.01).
|
11751493 |
2001 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Their aldosterone-producing adenomas harbored activating mutations of CTNNB1, encoding β-catenin in the Wnt cell-differentiation pathway, and expressed LHCGR and GNRHR, encoding gonadal receptors, at levels that were more than 100 times as high as the levels in other aldosterone-producing adenomas.
|
26397949 |
2015 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
The TCF4-binding regions significantly correlate with Wnt-responsive gene expression profiles derived from primary human adenomas and often behave as beta-catenin/TCF4-dependent enhancers in transient reporter assays.
|
18268006 |
2008 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The results of the current study suggest that up-regulation of the Wnt signaling pathway, including accumulation of mutant CTNNB1 in the nuclei, plays an important role in the tumorigenesis and development of adenoma in the pituitary gland.
|
11148558 |
2001 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The lower apoptotic activity of low-grade slightly elevated adenomas can be partly attributed to upregulated β-catenin pathway activity and downregulated c-Myc expression.
|
28533663 |
2017 |